SrasV1, Main, Exploration, bibRecord, 004358

Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals

Identifieur interne : 004358 ( Main/Exploration ); précédent : 004357; suivant : 004359

Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals

Auteurs : Linqi Zhang [États-Unis, République populaire de Chine] ; Fengwen Zhang [États-Unis] ; Wenjie Yu [États-Unis] ; Tian He [États-Unis] ; Jian Yu [États-Unis] ; Christopher E. Yi [États-Unis] ; Lei Ba [États-Unis] ; Wenhui Li [États-Unis] ; Michael Farzan [États-Unis] ; Zhiwei Chen [États-Unis] ; Kwok-Yung Yuen [République populaire de Chine] ; David Ho [États-Unis]

Source :

Journal of Medical Virology [ 0146-6615 ] ; 2006-01.

RBID : ISTEX:7D3F528E1F272CB6F83C9A6CA7AF684D10390EFC

Descripteurs français

English descriptors

KwdEn :
- Antibodies, Viral (blood), Antibodies, Viral (immunology), Disease Progression, Humans, Membrane Glycoproteins (immunology), Neutralization Tests, Nucleocapsid Proteins (immunology), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (physiopathology), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (immunology).
MESH :
- chemical , blood : Antibodies, Viral.
- chemical , immunology : Antibodies, Viral, Membrane Glycoproteins, Nucleocapsid Proteins, Viral Envelope Proteins.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- physiopathology : Severe Acute Respiratory Syndrome.
Teeft :
- Ace2, Antibody responses, Binding antibodies, Cell line, Cell lines, Chan, Coronavirus, Deceased group, Deceased patients, Detectable levels, Disease Progression, Disease outcome, Engl, Glycoprotein, High levels, Higher levels, Hong kong, Humans, Immune system, Leung, Lower panel, Neutralization Tests, Neutralizing, Neutralizing antibody, Novel coronavirus, Nucleocapsid, Peiris, Poutanen, Pseudotyped, Pseudotyped retrovirus, Receptor ace2, Respiratory syndrome, Retrovirus, Sars, Sars coronavirus, Sars patients, Sequential, Sequential samples, Serum samples, Spike Glycoprotein, Coronavirus, Syndrome, Temporal changes, Tsang, Upper panel, Virol, Wang, Wong, Yuen, Zhang.

Abstract

Most of the SARS‐CoV‐infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein‐specific and S glycoprotein‐specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS‐CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein‐specific and S glycoprotein‐specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS‐CoV‐infected patients. J. Med. Virol. 78:1–8, 2006. © 2005 Wiley‐Liss, inc.

Url:

https://api.istex.fr/ark:/67375/WNG-Q6PJJWFJ-S/fulltext.pdf

DOI: 10.1002/jmv.20499

Affiliations:

Le document en format XML

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<term>Protéines de l'enveloppe virale (immunologie)</term>
<term>Protéines nucléocapside (immunologie)</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
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<term>Protéines nucléocapside</term>
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<front><div type="abstract" xml:lang="en">Most of the SARS‐CoV‐infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein‐specific and S glycoprotein‐specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS‐CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein‐specific and S glycoprotein‐specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS‐CoV‐infected patients. J. Med. Virol. 78:1–8, 2006. © 2005 Wiley‐Liss, inc.</div>
</front>
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Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals

Antibody responses against SARS coronavirus are correlated with disease outcome of infected individuals

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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